Lines of research

27/11/2017

           

 Neuropathic pain is usually defined as a direct consequence of an injury or illness that affects the somatosensory system, and could be classified as central or peripheral. This kind of pain is characterized as burning pain, followed by the feeling of allodynia, which is the kind of pain felt with an innocuous stimuli and hyperalgesia, which is an increase in pain sensitization.

There are many types of neuropathic pain, LAND researches focus on the following:

  • Trigeminal Neuralgia (TN): Described by the International Association for the Study of Pain (IASP) as a unilateral painful disorder that is characterized by brief, electric-shock-like pain, is abrupt in onset and termination.
  • Chronic Constriction Injury (CCI): peripheral neuropathy of the sciatic nerve.
  • Diabetic Neuropathy (NDP): an ordinary complication, however, devastating in Diabetes Mellitus, with a great variety of clinical manifestations, characterized by the damaged of many peripheral nerves.

Besides neuropathic pain, another line of research in out laboratory is musculoskeletal pain, which inflicts pain in bones, muscles, cartilage and other surrounding structures.

Yet, we adopt three treatment techniques for our pain experimental models: photobiostimulation and neuronal mobilization, non-invasive methods, and Gabapentin, an adjuvant drug for the treatment of partial seizures and neuropathic pain.

Laser therapy being applied in Trigeminal Neuralgia (left) and sciatic nerve in experimental rats.

 

We also make use of behavioral testes to evaluate the animals’  nociceptive sensitization, such as pressure test onto their paws, described by Randall & Sellito, Mechanical Allodynia  test with Von Frey Filaments, Mechanic hyperalgesia with Electronic Von Frey  and Thermal Hyperalgesia  with the Hargreaves test.

The Hargreveas Test done in an experimental animal

Mechanical Hyperalgesia test with Electronic Von Frey (left) and Randall/Sellito paw-pressure test

Allodynia test with Von Frey Filaments